Our Predictions
Betis are playing at home, favored by most bookies at around 2.00 odds. Lyon are missing some key players and have struggled away, while Betis have shown solid home form despite injuries.
Both teams usually find the net in Europa League matches, with Lyon scoring and conceding often on the road, and Betis boasting firepower but also gaps at the back. Bookies price 'Yes' at 1.70, making this a likely scenario.
Recent matches for both teams have seen at least three goals, and over 2.5 goals sits at 1.87 odds. With both teams' strengths and defensive absences, goal chances are set to be high.
Accumulator odds
Welcome to Extratips! Betis vs Lyon Prediction & Match Preview
Get ready for an exciting Europa League clash as Real Betis welcome Lyon to Estadio La Cartuja on November 6, 2025, at 20:00. Both teams have a lot on the line—with key injuries and momentum from recent matches sure to play a role. Betis haven't beaten Lyon in two previous meetings (one draw, one loss), and both sides have mixed form in their last five domestic and European games. The bookies see Betis as favorites, with their odds hovering near even, while Lyon are clear underdogs. Currently, Betis sit just inside the Europa League knockout spots, while Lyon are chasing points in a tight group. Recent games show that Betis are strong at home but sometimes concede late, and Lyon's away games have delivered plenty of goals. Isco and Aitor Ruibal will be absent for Betis, while Lyon miss Nuamah and Mangala—so expect some tactical changes. Will Betis break their Lyon hoodoo, or can the visitors spring a surprise? Tune in for a tense, goal-filled encounter with plenty riding on every moment!